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Difference Between ADH And Aldosterone


Hormones secreted by the endocrine and exocrine glands play a major role in maintaining anatomy and physiology of the body. ADH and aldosterone are two such critical hormones that are essential to the functioning of the body and its structure. Both are involved in water reabsorption in the nephrons. However, the most prominent difference between these hormones is the type of gland secreting them. They are also synthesized in different parts of the body. Let’s tell you everything about ADH and aldosterone.

Comparison Table

Other NameVasopressinMineralocorticoid
Type of HormonePeptideSteroid
SynthesisHypothalamusZona glomerulosa
SecretionPituitary GlandAdrenal Cortex
Mechanism of ActionOpens pores in kidneysIncreases sodium pump activity
FunctionControl blood volume
and blood pressure
Absorption of sodium to
maintain salt and water balance
Effect on
Distal Tubules
Increases permeability to waterIncreases permeability to sodium ions
Effect on
Water Absorption
Directly increases absorptionCreates osmotic pressure
to increase water absorption
Blood PressureIncreasesNo effect
RegulationOsmotic pressureRenin, angiotensin,
and blood pressure

What is ADH?

ADH (antidiuretic hormone), also known as vasopressin, is a peptide hormone. It performs the job of retaining water in the human body by concentrating urine. Vasopressin is a combination of “vaso” and “pressing,” translating to squeezing blood vessels.


The osmoreceptors in the hypothalamus monitor the osmolarity of the blood. The hypothalamus is responsible for maintaining water balance in the body. It synthesizes ADH when the osmolarity of the blood decreases. It travels to the posterior pituitary gland, which secretes the hormone into the bloodstream. The pituitary gland acts as a storage space for the hormone and releases it when the blood pressure increases or decreases. When your body has low blood pressure, ADH comes into play to constrict arteries and veins and increases blood pressure. ADH helps you with different functions that manage blood pressure, including:

  • Increasing the volume of blood pressure by facilitating the reabsorption of water by the kidneys.
  • Increasing blood volume when a person is suffering from hypovolemia
  • Reabsorbing water and lowering the levels of ADH to dilute blood highly concentrated with sodium.

What is Aldosterone?

Aldosterone is the main mineralocorticoid of the adrenal cortex. It is produced in the zona glomerulosa in the adrenal gland and helps in the conservation of sodium ions. Aldosterone is a part of the renin–angiotensin–aldosterone system. The renin angiotensin system plays a role in renal physiology. It works on the collecting ducts and distal tubules to preserve water. The process takes place through nephrons.


The nephrons in the kidney secrete renin that travels to the liver and converts renin into angiotensin I. Angiotensin I is then converted into angiotensin II in the lungs. Angiotensin II moves to the adrenal glands to produce aldosterone.

An increased amount of potassium in blood or plasma signals the release of aldosterone. A low renal perfusion decrease in sodium concentration may also stimulate hormone production. Aldosterone influences sodium and potassium pumps to reabsorb sodium and excrete potassium. As a result, it impacts blood pressure, blood volume, and water retention.

Similarities Between ADH and Aldosterone

  • These hormones work in the collecting ducts and distal tubules in the kidney.
  • ADH and aldosterone facilitate the reabsorption of water in the kidneys.
  • They are secreted under the stimulus of low blood pressure.

Difference Between ADH and Aldosterone



ADH prevents the production of dilute urine from retaining water in the body.


Aldosterone stimulates the absorption of sodium to maintain water and salt balance in the body.

Other Name


ADH (antidiuretic hormone) is also known as vasopressin.


On the other hand, aldosterone is also called a mineralocorticoid because of its function.

Type of Hormone


ADH is a peptide hormone contributing to water retention.


But, aldosterone is a steroid in nature, maintaining salt and water.

Production and Secretion


ADH is synthesized in the hypothalamus and secreted by the pituitary gland.


While, aldosterone is produced in the zona glomerulosa of the adrenal cortex and secreted from the adrenal gland.

Mechanism of Action


ADH works by increasing the permeability by opening pores in kidney epithelial tissues.


Alternatively, aldosterone performs by increasing the activity of sodium pumps in the cells.



The main function of ADH is to control blood volume and blood pressure in the body by retaining water.


At the same time, aldosterone contributes to the absorption of sodium to maintain salt and water balance in the body.

Effect on Distal Tubules


Increases the permeability of DCT and collecting tubules to water.


Conversely, it makes the collecting tubules and distal collecting tubules more permeable to sodium ions.

Effect on Water Absorption


Increases the water absorption from distal tubules directly.


But, aldosterone increases water reabsorption by creating an osmotic pressure.

Blood Pressure


ADH impacts blood pressure by constricting blood vessels leading to increased blood pressure.


Whereas, aldosterone does not have any effect on blood pressure.



ADH is regulated through osmotic pressure in the blood vessels.


Contrarily, aldosterone regulates through renin, angiotensin, and blood pressure.

The Bottom Line

ADH and aldosterone are important hormones in the body that contribute to water retention in the body. Despite their similar function, the main difference between ADH and aldosterone is their mechanism of action. ADH increases permeability by opening pores in kidney cells. Alternatively, aldosterone increases the activity of sodium pumps in the body. Moreover, ADH or vasopressin contributes to blood pressure, while aldosterone does not impact arteries, veins, or capillaries.


What is the relationship between ADH and aldosterone?

ADH contributes to water reabsorption, whereas aldosterone also plays a role in sodium reabsorption. Aldosterone increases blood pressure and blood volume by stimulating water and sodium reabsorption.

Does aldosterone stimulate ADH release?

Aldosterone acts on the kidneys to increase fluid and sodium retention. It also stimulates the release of ADH from the posterior pituitary gland, which helps increase fluid retention.

How do ADH and aldosterone affect urine output?

ADH and aldosterone both work to retain water in the body. However, the mechanism of action is different. ADH opens pores in kidney tissues, while aldosterone increases the activity of sodium pumps.

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